Nts have been metoprolol (77 ) and carvedilol (thirteen ). The overall mortality fee was 30 . Among the

Nts were metoprolol (77 ) and carvedilol (thirteen ). The general mortality charge was 30 . Amid patients who have been previously getting -blockers, 181 (29.1 ) died from the ICU and 442 (70.9 ) were being discharged alive. Of the individuals who didn’t have a very former prescription for -blockers, 1,231 (thirty.seven ) died in the ICU and a pair of,775 (69.3 ) were being discharged alive. There was no statistically important association involving people aquiring a past prescription for -blockers and ICU mortality (chance ratio 0.94; 95 self confidence interval [CI] 0.eighty two to 1.08; p = .39). We more stratified sufferers within the basis of maximum heart price inside the to start with 24 several hours of ICU admission into those people having a heart fee >95 beats per moment and people with a heart price of < =95 beats per minute. There were no statistically significant association between patients who had a previous prescription for -blockers and ICU mortality in either group (risk ratio 0.91; 95 CI 0.77 to 1.06; p = 0.22) and (risk ratio 1.095; 95 CI 0.78 to 0.1.54; p = 0.60) respectively. Conclusions: Our study demonstrated no significant association between previous prescription for -blockers and ICU mortality. This held true even after further stratification of patients on the basis of highest heart rate in the first 24 hours of ICU admission. This result may be due to lack of effect of -blockers or short-term action of medication use. P043 Recognition and treatment of sepsis on labour ward?teaching information resources can improve knowledge J. Heaton, A. Boyce, L. Nolan, J. Johnston, A. Dukoff-Gordon, A. Dean, A. Molokhia Lewisham and Greenwich NHS Trust, London, UK Critical Care 2016, 20(Suppl 2):PCritical Care 2016, Volume 20 SupplPage 28 ofIntroduction: The UK Sepsis Trust aims to raise awareness of sepsis and recommends an evidence based treatment bundle for severe sepsis known as `The Sepsis Six' [1, 2]. An audit was completed on the Obstetric units of Lewisham and Greenwich NHS Trust, UK. We wanted to assess the impact of teaching and posters on improving knowledge. Methods: We gave an anonymous questionnaire to maternity staff to assess baseline knowledge. This tested respondent's on the diagnostic criteria for systemic inflammatory response syndrome (SIRS), sepsis, severe sepsis and their knowledge of the `Sepsis Six' treatment bundle for severe sepsis [1]. Our interventions consisted of 1:1 teaching and the provision of an information poster. A re-audit was performed in the same units a week later. Results: We initially audited 33 maternity staff and re-audited PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/8627573 PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/22316373 27. People re-audited documented that each one staff had gained one:one educating and 96 experienced witnessed the leaflet or poster. SIRS: To begin with, eighty two experienced heard of SIRS, could name on regular of only one.5/6 requirements and only fifty eight understood two requirements were necessary for that diagnosis. This improved to 100 , five.2/6 and eighty one respectively. SEPSIS: 52 could accurately determine sepsis, only three could define significant sepsis with workers equipped to call on ordinary only 0.eight of your extreme sepsis criteria. Their understanding also Letrozole enhanced to 70 , 63 and a pair of.four respectively. SEPSIS six Administration: Personnel realized four.8/6 with the Sepsis Six techniques for administration and 88 knew it was necessary inside an hour. There was a slight advancement to 5.5/6 for management and a stunning reduce in initiation of treatment to 85 . Conclusions: Our maternity employees have been at first conscious of SIRS and Sepsis and straightforward interventions required to diagnose and deal with patients, having said that their baseline knowl.